[TKI] TNIK

TNIK inhibitors

TNIK KD

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI

Rentosertib : first in class AI designed, in Phase III trial for IPF

CC(C)N1C=NC(=C1C1=NC=C(N1)C(=O)NC1=CC=C(C=C1)N1CCN(C)CC1)C1=CC=C(F)C=C1

NCB0846: most studies have used this compound.

O[C@@H](CC1)CC[C@@H]1OC2=CC=CC3=C2N=C(NC4=CC=C(N=CN5)C5=C4)N=C3

Osimertinib : based on the paper listed below.

COC1=C(NC2=NC=CC(=N2)C2=CN(C)C3=C2C=CC=C3)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C